Article
The contribution of parent-to-offspring transmission of telomeres to the heritability of telomere length in humans.
Human genetics - 1 Jan 2019
Delgado Dayana A, Zhang Chenan, Gleason Kevin, Demanelis Kathryn, Chen Lin S, Gao Jianjun, Roy Shantanu, Shinkle Justin, Sabarinathan Mekala, Argos Maria, Tong Lin, Ahmed Alauddin, Islam Tariqul, Rakibuz-Zaman Muhammad, Sarwar Golam, Shahriar Hasan, Rahman Mahfuzar, Yunus Muhammad, Doherty Jennifer A, Jasmine Farzana, Kibriya Muhammad G, Ahsan Habibul, Pierce Brandon L
Abstract excerpt
Leukocyte telomere length (LTL) is a heritable trait with two potential sources of heritability (h2): inherited variation in non-telomeric regions (e.g., SNPs that influence telomere maintenance) and variability in the lengths of telomeres in gametes that produce offspring zygotes (i.e., "direct" inheritance). Prior studies of LTL h2 have not attempted to disentangle these two sources. Here, we use a novel...
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