Article
Dysanapsis Genetic Risk Predicts Lung Function Across the Lifespan.
American journal of respiratory and critical care medicine - 15 Dec 2024
Debban Catherine L, Ambalavanan Amirthagowri, Ghosh Auyon, Li Zhonglin, Buschur Kristina L, Ma Yanlin, George Elizabeth, Pistenmaa Carrie, Bertoni Alain G, Oelsner Elizabeth C, Michos Erin D, Moraes Theo J, Jacobs David R, Christenson Stephanie, Bhatt Surya P, Kaner Robert J, Simons Elinor, Turvey Stuart E, Vameghestahbanati Motahareh, Engert James C, Kirby Miranda, Bourbeau Jean, Tan Wan C, Gabriel Stacey B, Gupta Namrata, Woodruff Prescott G, Subbarao Padmaja, Ortega Victor E, Bleecker Eugene R, Meyers Deborah A, Rich Stephen S, Hoffman Eric A, Barr R Graham, Cho Michael H, Bossé Yohan, Duan Qingling, Manichaikul Ani, Smith Benjamin M
Abstract excerpt
Rationale: Dysanapsis refers to a mismatch between airway tree caliber and lung size arising early in life. Dysanapsis assessed by computed tomography (CT) is evident by early adulthood and associated with chronic obstructive pulmonary disease (COPD) risk later in life. Objectives: By examining the genetic factors associated with CT-assessed dysanapsis, we aimed to elucidate its molecular underpinnings and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.