Article
A Comprehensive Clinicopathologic and Molecular Reappraisal of GLI1 -altered Mesenchymal Tumors with Pooled Outcome Analysis Showing Poor Survival in GLI1 - amplified Versus GLI1- rearranged Tumors.
The American journal of surgical pathology - 1 Oct 2024
Saoud Carla, Agaimy Abbas, Dermawan Josephine K, Chen Jie-Fu, Rosenblum Marc K, Dickson Brendan C, Dashti Nooshin, Michal Michael, Kosemehmetoglu Kemal, Din Nasir Ud, Albritton Karen, Agaram Narasimhan P, Antonescu Cristina R
Abstract excerpt
GLI1 -altered mesenchymal tumor is a recently described distinct pathologic entity with an established risk of malignancy, being defined molecularly by either GLI1 gene fusions or amplifications. The clinicopathologic overlap of tumors driven by the 2 seemingly distinct mechanisms of GLI1 activation is still emerging. Herein, we report the largest series of molecularly confirmed GLI1 -altered mesenchymal...
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