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Article

Sex-dependent interaction of PTGS2 with miR-146a as risk factor for melanoma and the impact of sex hormones in gene expression in skin cells.

Melanoma research - 1 Aug 2024

Orlandi Elisa, Ceccuzzi Laura, Belpinati Francesca, Rodolfo Monica, Malerba Giovanni, Trabetti Elisabetta, Gomez-Lira Macarena, Romanelli Maria Grazia

Abstract excerpt

Gender disparity in melanoma is a complex issue where sex hormones could be engaged. Differences in genetic variations are important in understanding the mechanisms of sex disparity in melanoma. Post-transcriptional regulation of prostaglandin-endoperoxide synthase (PTGS2) mRNA occurs through a complex interplay of specific trans-acting RNA-binding proteins and microRNAs. MiR-146a is a key player in melanoma,...

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Identifiers

PMID: 38934060
DOI: 10.1097/CMR.0000000000000978

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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