Article
A Possible Link of Genetic Variations in ER/IGF1R Pathway and Risk of Melanoma.
International journal of molecular sciences - 5 Mar 2020
Yuan Tze-An, Yourk Vandy, Farhat Ali, Guo Katherine L, Garcia Angela, Meyskens Frank L, Liu-Smith Feng
Abstract excerpt
The mechanism of gender disparity in cutaneous melanoma incidence remains unclear. Steroid hormones including estrogens have long been implicated in the course of melanoma, but the conclusion is controversial. Estrogen receptors (ERs) and insulin-like growth factor 1 receptor (IGF1R) show extensive crosstalk in cancer development, but how the ER/IGF1R network impacts melanoma is currently unclear. Here we studied...
Topics
Join the communities discussing this publication.