Article
Sex-specific effect of RNASEL rs486907 and miR-146a rs2910164 polymorphisms' interaction as a susceptibility factor for melanoma skin cancer.
Melanoma research - 1 Aug 2017
Sangalli Antonella, Orlandi Elisa, Poli Albino, Maurichi Andrea, Santinami Mario, Nicolis Morena, Ferronato Silvia, Malerba Giovanni, Rodolfo Monica, Gomez Lira Macarena
Abstract excerpt
The genetics of melanoma is complex and, in addition to environmental influences, numerous genes are involved or contribute toward melanoma predisposition. In this study, we evaluated the possible interaction between miR-146a and one of its putative targets ribonuclease L (RNASEL) in the risk of sporadic melanoma. Polymorphisms rs2910164 in miR-146a and rs486907 in the RNASEL gene have both independently been...
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