Article
A Nonsynonymous Substitution of Lhx3 Leads to Changes in Body Size in Dogs and Mice.
Genes - 4 Jun 2024
Dang Wanyi, Gao Dali, Lyu Guangqi, Irwin David M, Shang Songyang, Chen Junnan, Zhang Junpeng, Zhang Shuyi, Wang Zhe
Abstract excerpt
Lhx3 is a LIM-homeodomain transcription factor that affects body size in mammals by regulating the secretion of pituitary hormones. Akita, Shiba Inu, and Mame Shiba Inu dogs are Japanese native dog breeds that have different body sizes. To determine whether Lhx3 plays a role in the differing body sizes of these three dog breeds, we sequenced the Lhx3 gene in the three breeds, which led to the identification of an...
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