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Article

Dietary intervention rescues a bone porosity phenotype in a murine model of Neurofibromatosis Type 1 (NF1).

PloS one - 1 Jan 2024

O'Donohue Alexandra K, Li Xiaoying C, Lee Lucinda R, Vasiljevski Emily R, Little David G, Munns Craig F, Schindeler Aaron

Abstract excerpt

Neurofibromatosis type 1 (NF1) is a complex genetic disorder that affects a range of tissues including muscle and bone. Recent preclinical and clinical studies have shown that Nf1 deficiency in muscle causes metabolic changes resulting in intramyocellular lipid accumulation and muscle weakness. These can be subsequently rescued by dietary interventions aimed at modulating lipid availability and metabolism. It was...

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Source

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Identifiers

PMID: 38913608
DOI: 10.1371/journal.pone.0304778
PMCID: PMC11195983

Genes

NF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Dietary intervention rescues a bone porosity phenotype in a murine model of Neurofibromatosis Type 1 (NF1).PMID 38913608Read ↗

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