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Article

Vaginal Lactobacillus crispatus persistence following application of a live biotherapeutic product: colonization phenotypes and genital immune impact.

Microbiome - 21 Jun 2024

Armstrong Eric, Hemmerling Anke, Miller Steve, Huibner Sanja, Kulikova Maria, Crawford Emily, Castañeda Gloria R, Coburn Bryan, Cohen Craig R, Kaul Rupert

Abstract excerpt

BACKGROUND: Bacterial vaginosis (BV) increases HIV acquisition risk, potentially by eliciting genital inflammation. After BV treatment, the vaginal administration of LACTIN-V, a live biotherapeutic containing the Lactobacillus crispatus strain CTV-05, reduced BV recurrence and vaginal inflammation; however, 3 months after product cessation, CTV-05 colonization was only sustained in 48% of participants. RESULTS:...

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Identifiers

PMID: 38907268
DOI: 10.1186/s40168-024-01828-7
PMCID: PMC11191164

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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