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Identification of individuals from low template blood samples using whole transcriptome shotgun sequencing.

Forensic science international. Genetics - 1 Sept 2024

Jepsen Alberte Honoré, Kampmann Marie-Louise, Jacobsen Stine Bøttcher, Børsting Claus, Andersen Jeppe Dyrberg

Abstract excerpt

Biological trace samples consisting of very few cells pose a challenge to conventional forensic genetic DNA analysis. RNA may be an alternative to DNA when handling low template samples. Whereas each cell only contains two copies of an autosomal DNA segment, the transcriptome retains much of the genomic variation replicated in abundant RNA fragments. In this study, we describe the development of a prototype...

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PMID: 38905753
DOI: 10.1016/j.fsigen.2024.103089

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