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Article

Multiple roles for hypoxia inducible factor 1-alpha in airway epithelial cells during mucormycosis

20 Jun 2024

Abstract excerpt

During pulmonary mucormycosis, inhaled sporangiospores adhere to, germinate, and invade airway epithelial cells to establish infection. We provide evidence that HIF1α plays dual roles in airway epithelial cells during Mucorales infection. We observed an increase in HIF1α protein accumulation and increased expression of many known HIF1α-responsive genes during in vitro infection, indicating that HIF1α signaling is...

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PMID: 38902255
DOI: 10.1038/s41467-024-49637-8

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