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Article

Hypertriglyceridemia Results From an Impaired Catabolism of Triglyceride-Rich Lipoproteins in PLIN1-Related Lipodystrophy.

Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2024

Vergès Bruno, Vantyghem Marie-Christine, Reznik Yves, Duvillard Laurence, Rouland Alexia, Capel Emilie, Vigouroux Corinne

Abstract excerpt

BACKGROUND: Pathogenic variants in PLIN1-encoding PLIN1 (perilipin-1) are responsible for an autosomal dominant form of familial partial lipodystrophy (FPL) associated with severe insulin resistance, hepatic steatosis, and important hypertriglyceridemia. This study aims to decipher the mechanisms of hypertriglyceridemia associated with PLIN1-related FPL. METHODS: We performed an in vivo lipoprotein kinetic study...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38899472
DOI: 10.1161/ATVBAHA.124.320774

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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