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Article

The binding mechanism of an anti-multiple myeloma antibody to the human GPRC5D homodimer

19 Jun 2024

Abstract excerpt

GPRC5D is an atypical Class C orphan G protein-coupled receptor. Its high expression on the surface of multiple myeloma cells has rendered it an attractive target for therapeutic interventions, including monoclonal antibodies, CAR-T cells, and T-cell engagers. Despite its therapeutic potential, the insufficient understanding regarding of the receptor's structure and antibody recognition mechanism has impeded the...

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PMID: 38898050
DOI: 10.1038/s41467-024-49625-y

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