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Article

Comprehensive genomic profiling of Taiwanese triple-negative breast cancer with a large targeted sequencing panel.

Journal of the Chinese Medical Association : JCMA - 1 Aug 2025

Huang Chi-Cheng, Yeh Yi-Chen, Cheng Han-Fang, Chen Bo-Fang, Liu Chun-Yu, Tsai Yi-Fang, Ho Hsiang-Ling, Tseng Ling-Ming

Abstract excerpt

BACKGROUND: Breast cancer is a leading cause of cancer-related deaths in women, particularly those with the triple-negative (TN) phenotype. Although novel therapeutic options are emerging, most are biomarker-driven. This study used comprehensive genomic profiling (CGP) via targeted sequencing to identify actionable alterations in a TN subcohort of the VGH-TAYLOR study. METHODS: The study included patients with...

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Identifiers

PMID: 40537918
DOI: 10.1097/JCMA.0000000000001258
PMCID: PMC12637152

Genes

BRCA1
BRCA2
PIK3CA
PTEN
AKT1
ERBB2
ERBB3
PALB2

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