Exploring gut microbiota’s role in rheumatic valve disease: insights from a Mendelian randomization study and mediation analysis

Abstract excerpt

Background Investigating the relationship between gut microbiota and Rheumatic Valve Disease (RVD) is crucial for understanding the disease’s etiology and developing effective interventions. Our study adopts a novel approach to examine the potential causal connections between these factors. Methods Utilizing a two-sample Mendelian Randomization (MR) framework, we incorporated a multi-variable MR (MVMR) strategy...

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