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Article

Association of early menarche with breast tumor molecular features and recurrence

17 Jun 2024

Abstract excerpt

Abstract Background Early menarche is an established risk factor for breast cancer but its molecular contribution to tumor biology and prognosis remains unclear. Methods We profiled transcriptome-wide gene expression in breast tumors (N = 846) and tumor-adjacent normal tissues (N = 666) from women in the Nurses’ Health Studies (NHS) to investigate whether early menarche (age < 12) is associated with tumor...

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PMID: 38886818
DOI: 10.1186/s13058-024-01839-0

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