Article
A multicenter prospective study of single nucleotide polymorphisms in the PDCD1 (programmed cell death 1) gene in patients with metastatic lung adenocarcinoma treated with pembrolizumab.
Lung cancer (Amsterdam, Netherlands) - 1 Jun 2026
Chiari Rita, Russano Marco, Leva Giacomo, Emili Rita, Fiorenti Matteo, Vincenzi Bruno, Catalano Vincenzo, De Lisa Mariagrazia, Santinelli Alfredo, Gulini Anna Elisa, Marcantognini Giulia, Bisonni Renato, Graziano Francesco, Ruzzo Annamaria
Abstract excerpt
INTRODUCTION: Pembrolizumab, a monoclonal antibody targeting programmed death-1 (PD-1), improves outcomes in metastatic lung adenocarcinoma (MLA) expressing programmed death ligand-1 (PD-L1). Single nucleotide polymorphisms (SNPs) in the PDCD1 gene may impair PD-1 signaling and reduce the efficacy of pembrolizumab. We evaluated the impact of rs11568821 C>T, rs10204525 C>T, rs7421861 A>G, rs2227981 G>A, and...