Influence of matrix metalloproteinase 9 variant rs17576 on ischemic stroke risk and severity in acute coronary syndrome.

doi:10.1016/j.jstrokecerebrovasdis.2024.107824

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Article

Influence of matrix metalloproteinase 9 variant rs17576 on ischemic stroke risk and severity in acute coronary syndrome.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association - 1 Aug 2024

Bogari Neda M, Naffadi Hind Mansour, Babalghith Ahmad O, Azher Zohor Asaad, Abumansour Iman Sabri, Melibary Ehab M, Qattan Muneera, Alluhaibi Amaal M, Amin Amr A, Bogari Mustafa, Bogari Dema Neda, Obaid Rami, Allam Reem M

Abstract excerpt

BACKGROUND: Ischemic injury is a common mechanism in both ischemic stroke (IS) and acute coronary syndrome (ACS). Matrix metalloproteinase 9 (MMP-9), an endopeptidase that degrades extracellular matrix, is important in the pathogenesis of IS. The purpose of this study is to evaluate the association between the SNP rs17576 in MMP-9 gene with (1) the risk and severity of acute ischemic stroke in Saudi Arab...

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PMID: 38880366
DOI: 10.1016/j.jstrokecerebrovasdis.2024.107824

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