Article
Genetic and environmental interactions contribute to immune variation in rewilded mice.
Nature immunology - 1 Jul 2024
Oyesola Oyebola, Downie Alexander E, Howard Nina, Barre Ramya S, Kiwanuka Kasalina, Zaldana Kimberly, Chen Ying-Han, Menezes Arthur, Lee Soo Ching, Devlin Joseph, Mondragón-Palomino Octavio, Souza Camila Oliveira Silva, Herrmann Christin, Koralov Sergei B, Cadwell Ken, Graham Andrea L, Loke P'ng
Abstract excerpt
The relative and synergistic contributions of genetics and environment to interindividual immune response variation remain unclear, despite implications in evolutionary biology and medicine. Here we quantify interactive effects of genotype and environment on immune traits by investigating C57BL/6, 129S1 and PWK/PhJ inbred mice, rewilded in an outdoor enclosure and infected with the parasite Trichuris muris....
Topics
- Animals
- Trichuris
- Trichuriasis
- Mice
- Mice, Inbred C57BL
- Gene-Environment Interaction
- Hyaluronan Receptors
- B-Lymphocytes
- Genotype
- Interferon-gamma