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Association of CYP27B1 gene polymorphisms with pulmonary tuberculosis and vitamin D levels.

Gene - 15 Nov 2024

Murugesan Harishankar, Sampath Pavithra, A Vamsi Kumar, R Srividhya, Veerasamy Athikesavan, Ranganathan Uma Devi, Paramasivam Selvaraj, Bethunaickan Ramalingam

Abstract excerpt

BACKGROUND AND OBJECTIVES: Genetic factors are reported to be connected with tuberculosis (TB) infection. Studies have shown that genetic variations in genes involved in the vitamin D pathway influence the levels of vitamin D found in the bloodstream (serum). Cyp27b1 (1α-hydroxylase) is an enzyme that activates the synthesis of bioactive vitamin D3 by hydroxylation of 25(OH)D3.The in vitro studies reported rare...

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Identifiers

PMID: 38876405
DOI: 10.1016/j.gene.2024.148679

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