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Recombination and amino acid point mutations in VP3 exhibit a synergistic effect on increased virulence of rMDPV

13 Jun 2024

Abstract excerpt

Recombinant Muscovy duck parvovirus (rMDPV) is a product of genetic recombination between classical Muscovy duck parvovirus (MDPV) and goose parvovirus (GPV). The recombination event took place within a 1.1-kb DNA segment located in the middle of the VP3 gene, and a 187-bp sequence extending from the P9 promoter to the 5′ initiation region of the Rep1 ORF. This resulted in the alteration of five amino acids...

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PMID: 38869140
DOI: 10.1080/21505594.2024.2366874

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