Article
Neuroblastoma Predisposition and Surveillance-An Update from the 2023 AACR Childhood Cancer Predisposition Workshop.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2024
Kamihara Junne, Diller Lisa R, Foulkes William D, Michaeli Orli, Nakano Yoshiko, Pajtler Kristian W, Perrino Melissa, Scollon Sarah R, Stewart Douglas R, Voss Stephan, Weksberg Rosanna, Hansford Jordan R, Brodeur Garrett M
Abstract excerpt
Genetic predisposition to neuroblastoma (NB) is relatively rare. Only 1% to 2% of patients have a family history of NB, 3% to 4% of cases present with bilateral or multifocal primary tumors, and occasional patients have syndromes that are associated with increased NB risk. Previously, a germline pathogenic variant (GPV) in PHOX2B was associated with Hirschsprung disease and congenital central hypoventilation...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.