Article
Retinoblastoma and Neuroblastoma Predisposition and Surveillance.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2017
Kamihara Junne, Bourdeaut Franck, Foulkes William D, Molenaar Jan J, Mossé Yaël P, Nakagawara Akira, Parareda Andreu, Scollon Sarah R, Schneider Kami Wolfe, Skalet Alison H, States Lisa J, Walsh Michael F, Diller Lisa R, Brodeur Garrett M
Abstract excerpt
Retinoblastoma (RB) is the most common intraocular malignancy in childhood. Approximately 40% of retinoblastomas are hereditary and due to germline mutations in the RB1 gene. Children with hereditary RB are also at risk for developing a midline intracranial tumor, most commonly pineoblastoma. We recommend intensive ocular screening for patients with germline RB1 mutations for retinoblastoma as well as...
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