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Article

Development of a live cell assay for the zinc transporter ZnT8.

SLAS discovery : advancing life sciences R & D - 1 Jul 2024

Azzollini Lucia, Prete Dolores Del, Wolf Gernot, Klimek Christoph, Saggioro Mattia, Ricci Fernanda, Christodoulaki Eirini, Wiedmer Tabea, Ingles-Prieto Alvaro, Superti-Furga Giulio, Scarabottolo Lia

Abstract excerpt

Zinc is an essential trace element that is involved in many biological processes and in cellular homeostasis. In pancreatic β-cells, zinc is crucial for the synthesis, processing, and secretion of insulin, which plays a key role in glucose homeostasis and which deficiency is the cause of diabetes. The accumulation of zinc in pancreatic cells is regulated by the solute carrier transporter SLC30A8 (or Zinc...

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PMID: 38848895
DOI: 10.1016/j.slasd.2024.100166

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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