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Exploiting tertiary lymphoid structures gene signature to evaluate tumor microenvironment infiltration and immunotherapy response in colorectal cancer

23 May 2024

Abstract excerpt

Background Tertiary lymphoid structures (TLS) is a particular component of tumor microenvironment (TME). However, its biological mechanisms in colorectal cancer (CRC) have not yet been understood. We desired to reveal the TLS gene signature in CRC and evaluate its role in prognosis and immunotherapy response. Methods The data was sourced from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO)...

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PMID: 38846981
DOI: 10.3389/fonc.2024.1383096

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