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Molecular Pathology of Myeloid Neoplasms: Molecular Pattern Recognition.

Clinics in laboratory medicine - 1 Jun 2024

Sadigh Sam, Kim Annette S

Abstract excerpt

Despite the apparent complexity of the molecular genetic underpinnings of myeloid neoplasms, most myeloid mutational profiles can be understood within a simple framework. Somatic mutations accumulate in hematopoietic stem cells with aging and toxic insults, termed clonal hematopoiesis. These "old stem cells" mutations, predominantly in the epigenetic and RNA spliceosome pathways, act as "founding" driver...

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PMID: 38821648
DOI: 10.1016/j.cll.2023.08.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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