Article
ClpP2 modulates ClpXP assembly to promote multiple pathogenic phenotypes in Pseudomonas aeruginosa.
Proceedings of the National Academy of Sciences of the United States of America - 7 Apr 2026
Zhang Jia Jia, Mawla Gina D, Robinson Reed, Weinstein Arielle J, Baker Tania A
Abstract excerpt
In the opportunistic pathogen Pseudomonas aeruginosa (Pa), ClpXP proteases selectively degrade key transcriptional regulators (TRs), enabling dynamic control over phenotypes that promote pathogenesis and virulence. Here, we report that a natural Pa variant activates multiple pathogenic phenotypes by modulating ClpXP assembly dynamics through a spontaneous hypomorphic mutation in the canonical peptidase subunit...
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