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Article

Altered distribution of chronicity-deficient Pseudomonas aeruginosa mutant guides optimization of synthetic chronic wound model.

Microbiology (Reading, England) - 1 Jul 2026

Roberts Bethan, Laxton Claire S, Spencer Daniella L, Thaarup Ida, Heeb Stephan, Penfold Christopher N, Hardie Kim R

Abstract excerpt

Pseudomonas aeruginosa is commonly isolated from chronic wounds where it forms biofilms that are recalcitrant to current treatments, greatly impacting the morbidity and mortality of infected patients. Since P. aeruginosa dictates wound severity and treatment outcomes, this bacterium is an important target in the treatment of chronic wound infections. This study aimed to unravel the functional intricacies of a key...

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PMID: 42518270
DOI: 10.1099/mic.0.001719
PMCID: PMC13418428

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