Gene expression signatures in blood from a West African sepsis cohort define host response phenotypes.

doi:10.1038/s41467-024-48821-0

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Article

Gene expression signatures in blood from a West African sepsis cohort define host response phenotypes.

Nature communications - 30 May 2024

Chenoweth Josh G, Colantuoni Carlo, Striegel Deborah A, Genzor Pavol, Brandsma Joost, Blair Paul W, Krishnan Subramaniam, Chiyka Elizabeth, Fazli Mehran, Mehta Rittal, Considine Michael, Cope Leslie, Knight Audrey C, Elayadi Anissa, Fox Anne, Hertzano Ronna, Letizia Andrew G, Owusu-Ofori Alex, Boakye Isaac, Aduboffour Albert A, Ansong Daniel, Biney Eno, Oduro George, Schully Kevin L, Clark Danielle V

Abstract excerpt

Our limited understanding of the pathophysiological mechanisms that operate during sepsis is an obstacle to rational treatment and clinical trial design. There is a critical lack of data from low- and middle-income countries where the sepsis burden is increased which inhibits generalized strategies for therapeutic intervention. Here we perform RNA sequencing of whole blood to investigate longitudinal host...

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Identifiers

PMID: 38816375
DOI: 10.1038/s41467-024-48821-0
PMCID: PMC11139862

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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