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Genome-wide association study of social isolation in 63,497 Japanese individuals from the general population.

Translational psychiatry - 17 Feb 2026

Ohseto Hisashi, Inoue Kosuke, Takahashi Ippei, Obara Taku, Narita Akira, Ishikuro Mami, Orui Masatsugu, Murakami Keiko, Noda Aoi, Shinoda Genki, Takase Masato, Nakaya Naoki, Kogure Mana, Hatanaka Rieko, Nakaya Kumi, Chiba Ippei, Tokioka Sayuri, Kotozaki Yuka, Shimizu Atsushi, Tanno Kozo, Hozawa Atsushi, Tamiya Gen, Kondo Naoki, Kuriyama Shinichi

Abstract excerpt

Social isolation, characterized by a lack of social connections with family, friends, and others, is associated with adverse health outcomes. However, the genetic contribution to the susceptibility to social isolation remains unclear. This study aimed to identify genetic loci associated with social isolation using the Lubben Social Network Scale (LSNS-6) in a Japanese population. The Tohoku Medical Megabank...

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Identifiers

PMID: 41702882
DOI: 10.1038/s41398-026-03896-9
PMCID: PMC13004915

Genes

ACADSB
HMX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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