Article
Optimizing the detection of hereditary predisposition in women with epithelial ovarian cancer: nationwide implementation of the Tumor-First workflow.
Familial cancer - 1 Nov 2024
Witjes Vera M, Hermkens Dorien M A, Swillens Julie E M, Smolders Yvonne H C M, Mourits Marian J E, Ausems Margreet G E M, de Hullu Joanne A, Ligtenberg Marjolijn J L, Hoogerbrugge Nicoline
Abstract excerpt
Genetic testing in patients with ovarian carcinoma (OC) is crucial, as around 10-15% of these women have a genetic predisposition to OC. Although guidelines have recommended universal germline testing for all patients with OC for a decade, implementation has proved challenging, thus resulting in low germline-testing rates (around 30-50%). Many new initiatives to improve genetic-testing rates have emerged, but...
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