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Opportunities to improve detection of genetic predisposition for ovarian cancer applying the Tumor-First workflow.

Familial cancer - 4 Aug 2026

Witjes Vera M, de Hullu Joanne A, van Remortele Angela, Vreede Lilian, Simons Michiel, Hoogerbrugge Nicoline, Ligtenberg Marjolijn J L

Abstract excerpt

Genetic testing in ovarian carcinoma (OC) patients is very important for patients and their relatives. The Tumor-First workflow uses a tumor DNA test to stratify germline testing for hereditary cancer predisposition as well as treatment options with PARP inhibitors. This workflow is adopted and successfully implemented nationwide. Here, we evaluated recent tumor DNA testing rates in the Netherlands to identify...

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Identifiers

PMID: 42550332
DOI: 10.1007/s10689-026-00592-x
PMCID: PMC13437641

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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