Evolution of genetic assessment for BRCA-associated gynaecologic malignancies: a Canadian multisociety roadmap.

doi:10.1136/jmedgenet-2018-105472

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Article

Evolution of genetic assessment for BRCA-associated gynaecologic malignancies: a Canadian multisociety roadmap.

Journal of medical genetics - 1 Sept 2018

McCuaig Jeanna M, Stockley Tracy L, Shaw Patricia, Fung-Kee-Fung Michael, Altman Alon D, Bentley James, Bernardini Marcus Q, Cormier Beatrice, Hirte Hal, Kieser Katharina, MacMillan Andree, Meschino Wendy S, Panabaker Karen, Perrier Renee, Provencher Diane, Schrader Kasmintan A, Serfas Kimberly, Tomiak Eva, Wong Nora, Young Sean S, Gotlieb Walter Henri, Hoskins Paul, Kim Raymond H

Abstract excerpt

The landscape of genetic testing in ovarian cancer patients has changed dramatically in recent years. The therapeutic benefits of poly ADP-ribose polymerase (PARP) inhibitors in treatment of BRCA1/2-related ovarian cancers has resulted in an increased demand and urgency for genetic testing results, while technological developments have led to widespread use of multi-gene cancer panels and development of tumour...

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PMID: 30042185
DOI: 10.1136/jmedgenet-2018-105472
PMCID: PMC6119348

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