Article
Donor genetic burden for cerebrovascular risk and kidney transplant outcome.
Journal of nephrology - 1 Jul 2024
Collins Kane E, Gilbert Edmund, Mauduit Vincent, Benson Katherine A, Elhassan Elhussein A E, O'Seaghdha Conall, Hill Claire, McKnight Amy Jayne, Maxwell Alexander P, van der Most Peter J, de Borst Martin H, Guan Weihua, Jacobson Pamala A, Israni Ajay K, Keating Brendan J, Lord Graham M, Markkinen Salla, Helanterä Ilkka, Hyvärinen Kati, Partanen Jukka, Madden Stephen F, Limou Sophie, Cavalleri Gianpiero L, Conlon Peter J
Abstract excerpt
BACKGROUND AND HYPOTHESIS: Kidney grafts from donors who died of stroke and related traits have worse outcomes relative to grafts from both living donors and those who died of other causes. We hypothesise that deceased donors, particularly those who died of stroke, have elevated polygenic burden for cerebrovascular traits. We further hypothesise that this donor polygenic burden is associated with inferior graft...
Topics
- Humans
- Kidney Transplantation
- Male
- Female
- Middle Aged
- Adult
- Graft Survival
- Stroke
- Hypertension