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Article

RTCpredictor: identification of read-through chimeric RNAs from RNA sequencing data.

Briefings in bioinformatics - 23 May 2024

Singh Sandeep, Shi Xinrui, Haddox Samuel, Elfman Justin, Ahmad Syed Basil, Lynch Sarah, Manley Tommy, Piczak Claire, Phung Christopher, Sun Yunan, Sharma Aadi, Li Hui

Abstract excerpt

Read-through chimeric RNAs are being recognized as a means to expand the functional transcriptome and contribute to cancer tumorigenesis when mis-regulated. However, current software tools often fail to predict them. We have developed RTCpredictor, utilizing a fast ripgrep tool to search for all possible exon-exon combinations of parental gene pairs. We also added exonic variants allowing searches containing...

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PMID: 38796690
DOI: 10.1093/bib/bbae251
PMCID: PMC11128028

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