Article
Tandem RNA chimeras contribute to transcriptome diversity in human population and are associated with intronic genetic variants.
PloS one - 1 Jan 2014
Greger Liliana, Su Jing, Rung Johan, Ferreira Pedro G, Lappalainen Tuuli, Dermitzakis Emmanouil T, Brazma Alvis
Abstract excerpt
Chimeric RNAs originating from two or more different genes are known to exist not only in cancer, but also in normal tissues, where they can play a role in human evolution. However, the exact mechanism of their formation is unknown. Here, we use RNA sequencing data from 462 healthy individuals representing 5 human populations to systematically identify and in depth characterize 81 RNA tandem chimeric transcripts,...
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