Article
Incremental increases in physiological fluid shear progressively alter pathogenic phenotypes and gene expression in multidrug resistant Salmonella.
Gut microbes - 1 Jan 2000
Yang Jiseon, Barrila Jennifer, Nauman Eric A, Nydam Seth D, Yang Shanshan, Park Jin, Gutierrez-Jensen Ami D, Castro Christian L, Ott C Mark, Buss Kristina, Steel Jason, Zakrajsek Anne D, Schuff Mary M, Nickerson Cheryl A
Abstract excerpt
The ability of bacteria to sense and respond to mechanical forces has important implications for pathogens during infection, as they experience wide fluid shear fluctuations in the host. However, little is known about how mechanical forces encountered in the infected host drive microbial pathogenesis. Herein, we combined mathematical modeling with hydrodynamic bacterial culture to profile transcriptomic and...
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