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Host attachment and fluid shear are integrated into a mechanical signal regulating virulence in <i>Escherichia coli</i> O157:H7

13 Apr 2015

Abstract excerpt

Enterohemorrhagic Escherichia coli (EHEC) is a foodborne pathogen causing hemorrhagic colitis and hemolytic uremic syndrome. EHEC colonizes the intestinal tract through a range of virulence factors encoded by the locus of enterocyte effacement (LEE), as well as Shiga toxin. Although the factors involved in colonization and disease are well characterized, how EHEC regulates its expression in response to a host...

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PMID: 25870295
DOI: 10.1073/pnas.1422986112

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