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Article

In vivo rescue of genetic dilated cardiomyopathy by systemic delivery of nexilin.

Genome biology - 23 May 2024

Shao Yanjiao, Liu Canzhao, Liao Hsin-Kai, Zhang Ran, Yuan Baolei, Yang Hanyan, Li Ronghui, Zhu Siting, Fang Xi, Rodriguez Esteban Concepcion, Chen Ju, Izpisua Belmonte Juan Carlos

Abstract excerpt

BACKGROUND: Dilated cardiomyopathy (DCM) is one of the most common causes of heart failure. Multiple identified mutations in nexilin (NEXN) have been suggested to be linked with severe DCM. However, the exact association between multiple mutations of Nexn and DCM remains unclear. Moreover, it is critical for the development of precise and effective therapeutics in treatments of DCM. RESULTS: In our study, Nexn...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38783323
DOI: 10.1186/s13059-024-03283-x
PMCID: PMC11112773

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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