Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

EV71 5'UTR interacts with 3D protein affecting replication through the AKT-mTOR pathway.

Virology journal - 22 May 2024

Xu Xiaoying, Ma Shao, Liu Ziwei, Yuan Haowen, Wang Yao, Chen Mengting, Du Mengyu, Kan Haopeng, Wang Zequn, Chong Xiaowen, Wen Hongling

Abstract excerpt

BACKGROUND: EV71 is one of the important pathogens of Hand-foot-and-mouth disease (HFMD), which causes serious neurological symptoms. Several studies have speculated that there will be interaction between 5'UTR and 3D protein. However, whether 5'UTR interacts with the 3D protein in regulating virus replication has not been clarified. METHODS: Four 5'UTR mutation sites (nt88C/T, nt90-102-3C, nt157G/A and nt574T/A)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5' Untranslated Regions
Share to Autophagy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chlorocebus aethiops

Share to Enterovirus A, Human

Share to Proto-Oncogene Proteins c-akt

Share to TOR Serine-Threonine Kinases

Share to Vero Cells

Share to Viral Nonstructural Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 38778344
DOI: 10.1186/s12985-024-02385-z
PMCID: PMC11110317

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

EV71 5'UTR interacts with 3D protein affecting replication through the AKT-mTOR pathway.PMID 38778344Read ↗

Enterovirus 71 VP1 Protein Regulates Viral Replication in SH-SY5Y Cells via the mTOR Autophagy Signaling PathwaySemantic proximity Read ↗

Beclin1 Binds to Enterovirus 71 3D Protein to Promote the Virus ReplicationSemantic proximity Read ↗

The glycine locating at random coil of picornaviruses VP3 enhances viral pathogenicity by targeting p53 to promote apoptosis and autophagySemantic proximity Read ↗

Interplay between Autophagy and Herpes Simplex Virus Type 1: ICP34.5, One of the Main ActorsSemantic proximity Read ↗

Enterovirus 71 antagonizes the inhibition of the host intrinsic antiviral factor A3GSemantic proximity Read ↗

Interaction between PHB2 and Enterovirus A71 VP1 Induces Autophagy and Affects EV-A71 InfectionSemantic proximity Read ↗

Polypyrimidine Tract-Binding Protein Regulates Enterovirus 71 Translation Through Interaction with the Internal Ribosomal Entry SiteSemantic proximity Read ↗

IPEC-J2 Autophagy Induced by TLR4 and NSP6 Interactions Facilitate Porcine Epidemic Diarrhea Virus ReplicationSemantic proximity Read ↗

Heat shock protein A1 inhibits the replication of foot-and-mouth disease virus by degrading viral RNA polymerase 3D through chaperone-mediated autophagySemantic proximity Read ↗

Enterovirus 71 induces autophagy by regulating has-miR-30a expression to promote viral replicationSemantic proximity Read ↗

Inhibition of EV71 replication by an interferon-stimulated gene product L3HYPDHSemantic proximity Read ↗

PolyC-Binding Protein 1 Interacts with 5′-Untranslated Region of Enterovirus 71 RNA in Membrane-Associated Complex to Facilitate Viral ReplicationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.