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A multi-trait GWAS identifies novel genes influencing albuminuria.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 20 Dec 2024

Tsao Hsiao-Mei, Lai Tai-Shuan, Chang Yi-Cheng, Hsiung Chia-Ni, Tsai I-Jung, Chou Yu-Hsiang, Wu Vin-Cent, Lin Shuei-Liong, Chen Yung-Ming

Abstract excerpt

BACKGROUND: Albuminuria is common and is associated with increased risks of end-stage kidney disease and cardiovascular diseases, yet its underlying mechanism remains obscure. Previous genome-wide association studies (GWAS) for albuminuria did not consider gene pleiotropy and primarily focused on European ancestry populations. This study adopted a multi-trait analysis of GWAS (MTAG) approach to jointly analyze...

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PMID: 38772745
DOI: 10.1093/ndt/gfae114

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