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Article

Identification of GPX4 as a therapeutic target for lung adenocarcinoma after EGFR-TKI resistance

1 May 2022

Abstract excerpt

Background: Tyrosine kinase inhibitor (TKI) treatment has significantly improved the prognosis of oncogenic-driven lung adenocarcinoma (LUAD). However, drug resistance limits the long-term benefits of patients. Therefore, there is a pressing need to explore the mechanism of TKI resistance and identify new therapeutic targets. It is possible to overcome TKI resistance by inducing tumor cell death through a new...

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PMID: 35693278
DOI: 10.21037/tlcr-22-318

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