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Article

Phenotypic amikacin resistance may not indicate poor response to amikacin in Mycobacterium avium complex pulmonary disease.

Antimicrobial agents and chemotherapy - 5 Jun 2024

Minuk L M, Brode S K, Mehrabi M, Sharma M K, Stobart M, Soualhine H, Marras T K

Abstract excerpt

When using amikacin to treat Mycobacterium avium complex pulmonary disease (MAC-PD), a minimum inhibitory concentration resistance breakpoint of ≥64 mcg/mL is recommended. We explored whether amikacin resistance characterized by phenotypic drug susceptibility testing was associated with clinical outcomes or mutational resistance in a retrospective cohort of patients with MAC-PD. Despite little aminoglycoside...

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Identifiers

PMID: 38758004
DOI: 10.1128/aac.00084-24
PMCID: PMC11620508

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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