Population dynamics of potentially harmful haplotypes: a pedigree analysis.

doi:10.1186/s12864-024-10407-x

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Article

Population dynamics of potentially harmful haplotypes: a pedigree analysis.

BMC genomics - 16 May 2024

Arias Katherine D, Fernández Iván, Gutiérrez Juan Pablo, Álvarez Isabel, Goyache Félix

Abstract excerpt

BACKGROUND: The identification of low-frequency haplotypes, never observed in homozygous state in a population, is considered informative on the presence of potentially harmful alleles (candidate alleles), putatively involved in inbreeding depression. Although identification of candidate alleles is challenging, studies analyzing the dynamics of potentially harmful alleles are lacking. A pedigree of the highly...

Topics

Pedigree
Haplotypes
Animals
Alleles
Polymorphism, Single Nucleotide
Swine
Population Dynamics
Female
Male
Gene Frequency

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Identifiers

PMID: 38755557
DOI: 10.1186/s12864-024-10407-x
PMCID: PMC11097446

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