Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Heterogeneity, Bayesian thinking, and phenotyping in critical care: A primer.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists - 9 Sept 2024

Jones Timothy W, Hendrick Tanner, Chase Aaron M

Abstract excerpt

PURPOSE: To familiarize clinicians with the emerging concepts in critical care research of Bayesian thinking and personalized medicine through phenotyping and explain their clinical relevance by highlighting how they address the issues of frequent negative trials and heterogeneity of treatment effect. SUMMARY: The past decades have seen many negative (effect-neutral) critical care trials of promising...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bayes Theorem
Share to Critical Care

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phenotype

Share to Precision Medicine

Source

Identifiers

PMID: 38742459
DOI: 10.1093/ajhp/zxae139

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heterogeneity, Bayesian thinking, and phenotyping in critical care: A primer.PMID 38742459Read ↗

From ICU Syndromes to ICU Subphenotypes: Consensus Report and Recommendations for Developing Precision Medicine in the ICU.Semantic proximity Read ↗

Systematic Molecular Phenotyping: A Path Toward Precision Emergency Medicine?Semantic proximity Read ↗

Subphenotypes in critical care: translation into clinical practice.Semantic proximity Read ↗

Multimodal phenotyping of ARDS: design and preliminary insights from the prospective BIOWARE cohort for precision critical management.Semantic proximity Read ↗

[Research progress of Mendelian randomization analysis in intensive care medicine].Semantic proximity Read ↗

Genetic Variation and Response to Neurocritical Illness: a Powerful Approach to Identify Novel Pathophysiological Mechanisms and Therapeutic Targets.Semantic proximity Read ↗

A Machine Learning-Derived “Cryptic Shock” Phenotype Provides Incremental Prognostic Value and Supports Bedside Risk Stratification in Elderly Mechanically Ventilated Patients: A Multicenter Study with External ValidationSemantic proximity Read ↗

In silico study of medical decision-making for rare diseases: heterogeneity of decision-makers in a population improves overall benefitSemantic proximity Read ↗

Personalized medicine: genetic variation and loss of physiologic complexity are associated with mortality in 644 trauma patients.Semantic proximity Read ↗

Cardiogenic shock: diagnosis, phenotyping and management.Semantic proximity Read ↗

Cluster analysis driven by unsupervised latent feature learning of intensive care unit medications to identify novel pharmaco-phenotypes of critically ill patientsSemantic proximity Read ↗

Acute Respiratory Distress Syndrome Subphenotypes Respond Differently to Randomized Fluid Management Strategy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.