From ICU Syndromes to ICU Subphenotypes: Consensus Report and Recommendations for Developing Precision Medicine in the ICU.

doi:10.1164/rccm.202311-2086SO

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Article

From ICU Syndromes to ICU Subphenotypes: Consensus Report and Recommendations for Developing Precision Medicine in the ICU.

American journal of respiratory and critical care medicine - 15 Jul 2024

Gordon Anthony C, Alipanah-Lechner Narges, Bos Lieuwe D, Dianti Jose, Diaz Janet V, Finfer Simon, Fujii Tomoko, Giamarellos-Bourboulis Evangelos J, Goligher Ewan C, Gong Michelle Ng, Karakike Eleni, Liu Vincent X, Lumlertgul Nuttha, Marshall John C, Menon David K, Meyer Nuala J, Munroe Elizabeth S, Myatra Sheila N, Ostermann Marlies, Prescott Hallie C, Randolph Adrienne G, Schenck Edward J, Seymour Christopher W, Shankar-Hari Manu, Singer Mervyn, Smit Marry R, Tanaka Aiko, Taccone Fabio S, Thompson B Taylor, Torres Lisa K, van der Poll Tom, Vincent Jean-Louis, Calfee Carolyn S

Abstract excerpt

Critical care uses syndromic definitions to describe patient groups for clinical practice and research. There is growing recognition that a "precision medicine" approach is required and that integrated biologic and physiologic data identify reproducible subpopulations that may respond differently to treatment. This article reviews the current state of the field and considers how to successfully transition to a...

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PMID: 38687499
DOI: 10.1164/rccm.202311-2086SO
PMCID: PMC11273306

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