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Article

Alpha9alpha10 knockout mice show altered physiological and behavioral responses to signals in masking noise.

The Journal of the Acoustical Society of America - 1 May 2024

Mondul Jane A, Burke Kali, Morley Barbara, Lauer Amanda M

Abstract excerpt

Medial olivocochlear (MOC) efferents modulate outer hair cell motility through specialized nicotinic acetylcholine receptors to support encoding of signals in noise. Transgenic mice lacking the alpha9 subunits of these receptors (α9KOs) have normal hearing in quiet and noise, but lack classic cochlear suppression effects and show abnormal temporal, spectral, and spatial processing. Mice deficient for both the...

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Source

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Identifiers

PMID: 38738939
DOI: 10.1121/10.0025985
PMCID: PMC11093617

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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