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Article

Genetic polymorphisms in the Paraoxonase 1 gene and risk of ovarian epithelial carcinoma.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Aug 2008

Lurie Galina, Wilkens Lynne R, Thompson Pamela J, McDuffie Katharine E, Carney Michael E, Terada Keith Y, Goodman Marc T

Abstract excerpt

Oxidative stress during successive ovulations increases the opportunity for DNA damage to ovarian epithelial cells and the potential for malignant transformation. Paraoxonase 1 (PON1) is an endogenous free radical scavenger that reduces oxidative stress. The association of two common functional single nucleotide polymorphisms (SNP), rs854560 T>A and rs662 A>G, with the risk of epithelial ovarian cancer was...

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Identifiers

PMID: 18708400
DOI: 10.1158/1055-9965.EPI-08-0145
PMCID: PMC2729507

Genes

PON1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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