Article
Exome sequencing implicates ancestry-related Mendelian variation at SYNE1 in childhood-onset essential hypertension.
JCI insight - 8 May 2024
Copeland Ian, Wonkam-Tingang Edmond, Gupta-Malhotra Monesha, Hashmi S Shahrukh, Han Yixing, Jajoo Aarti, Hall Nancy J, Hernandez Paula P, Lie Natasha, Liu Dan, Xu Jun, Rosenfeld Jill, Haldipur Aparna, Desire Zelene, Coban-Akdemir Zeynep H, Scott Daryl A, Li Qing, Chao Hsiao-Tuan, Zaske Ana M, Lupski James R, Milewicz Dianna M, Shete Sanjay, Posey Jennifer E, Hanchard Neil A
Abstract excerpt
Childhood-onset essential hypertension (COEH) is an uncommon form of hypertension that manifests in childhood or adolescence and, in the United States, disproportionately affects children of African ancestry. The etiology of COEH is unknown, but its childhood onset, low prevalence, high heritability, and skewed ancestral demography suggest the potential to identify rare genetic variation segregating in a...
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