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Article

Increased susceptibility to Mycobacterium avium complex infection in miniature Schnauzer dogs caused by a codon deletion in CARD9.

Scientific reports - 6 May 2024

Mizukami Keijiro, Dorsey-Oresto Angella, Raj Karthik, Eringis Anna, Furrow Eva, Martin Errolyn, Yamanaka Daisuke, Kehl Alexandra, Kolicheski Ana, Jagannathan Vidhya, Leeb Tosso, Lionakis Michail S, Giger Urs

Abstract excerpt

Mammals are generally resistant to Mycobacterium avium complex (MAC) infections. We report here on a primary immunodeficiency disorder causing increased susceptibility to MAC infections in a canine breed. Adult Miniature Schnauzers developing progressive systemic MAC infections were related to a common founder, and pedigree analysis was consistent with an autosomal recessive trait. A genome-wide association study...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38710903
DOI: 10.1038/s41598-024-61054-x
PMCID: PMC11074286

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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